J D Cerna
Sanguinarine is a toxic alkaloid extracted from some plants, including Bloodroot ( Sanguinaria canadensis ), Mexican Prickly Poppy Argemone mexicana , Chelidonium majus and Macleaya cordata . It is also found in the root, stem and leaves of the Opium Poppy but not in the capsule.
Sanguinarine kills animal cells through its action on the Na + -K + -ATPase transmembrane protein. Epidemic dropsy is a disease that results from ingesting sanguinarine.
If applied to the skin, sanguinarine kills cells and may destroy tissue. In turn, the bleeding wound may produce a massive scab, called an Eschar . For this reason, sanguinarine is termed an escharotic.
In plants, sanguinarine is synthesized from dihydrosanguinarine through the action of Dihydrobenzophenanthridine oxidase (EC 1.5.3.12).
Notes
- ^ Alfredo C. Santos, Pacifica Adkilen (July 1932). "The Alkaloids of Argemon Mexicana". Journal of the American Chemical Society 54, No. 7 : 2923–2924.
- ^ Inhibition of Na + -K + -ATPase activity and ouabain binding by sanguinarine Barry J. R. Pitts, Laurence R. Meyerson, Ph. D, Drug Development Research, Volume 1, Issue 1.
- ^ Das M, Khanna SK (May 1997). "Clinicoepidemiological, toxicological, and safety evaluation studies on argemone oil". Critical reviews in toxicology 27 (3): 273–97. PMID 9189656.
- ^ Chelirubine, Macarpine, and Sanguinarine Biosynthesis International Union of Biochemistry and Molecular Biology, Recommendations on Biochemical & Organic Nomenclature, Symbols & Terminology etc., web interface
J D Cerna
advertisement. Overview. Alternate Names: John Dayton Cerna Filmography. Actor: Boys Life 2 (1997) .... Jack Gudmanson (segment "Alkali, Iowa") Alkali, Iowa (1996)
J.D. Cerna
Filmography of J.D. Cerna ... Boys Life 2. Actors: Eileen Brennan, Vincent D'Onofrio, Mary Beth Hurt, Miles Perlich, Brett Barsky, J.D.
J.D. Cerna Filmography
Actor: Boys Life 2 (1997) .... Jack Gudmanson (segment "Alkali, Iowa") Alkali, Iowa (1996) .... Jack Gudmanson ; Dead Dudes in the House (1991) (as John Dayton Cerna)
J.D. Cerna
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Overview. Alternate Names: John Dayton Cerna Filmography. Actor: Boys Life 2 (1997) .... Jack Gudmanson (segment "Alkali, Iowa") Alkali, Iowa (1996)